09:00 AM – 09:30 AM Welcome Conference objectives Why EoE needs a severity index Overview of severity indexes for other diseases How do we apply this to EoE
Amanda B. Muir, MD University of Pennsylvania Perelman School of Medicine, Children’s Hospital of Philadelphia
09:30 AM – 09:40 AM Video PDF Options for Measuring Symptom Severity Nirmala P. Gonsalves, MD, Northwestern University-Feinberg School of Medicine How to adapt the current validated metrics for more widespread clinical use Complications of EoE as markers of disease severity: food impaction stricture/dilation perforation Differences to consider in adults and children
09:40 AM – 09:50 AM Video PDF Correlates of Symptom Severity and Outcomes Gary W. Falk, MD, MS, University of Pennsylvania Perelman School of Medicine Jonathan Spergel, MD, PhD, University of Pennsylvania Perelman School of Medicine, Children’s Hospital of Philadelphia Thresholds for symptoms severity Clinical markers of severity: non-response to treatment multiple atopic conditions growth and nutrition (children); weight loss family history of EoE or strictures mental illness/anxiety/eating disorder Histologic fibrosis (dense or pan esophageal) Recurrent food impaction symptoms in children Decreased esophageal compliance (especially if not reversible or in childhood)
09:50 AM – 10:20 AM Group Discussion to Align on EoE Symptom Severity and Incorporation of Clinical Severity
Chris A. Liacouras, MD University of Pennsylvania Perelman School of Medicine, Children’s Hospital of Philadelphia
10:30 AM – 10:40 AM Video PDF Measuring Endoscopic Severity with EREFS Ikuo Hirano, MD, Northwestern University-Feinberg School of Medicine
10:40 AM – 10:50 AM Video PDF Thresholds for Endoscopic Severity Mirna Chehade, MD, MPH, Icahn School of Medicine at Mount Sinai Alain Schoepfer, PD, University of Lausanne
10:50 AM – 11:00 AM Video PDF Correlates of Endoscopic Severity and Outcomes Calies Menard-Katcher, MD,MPH, University of Colorado School of Medicine,Children’s Hospital Colorado Role of fibrostenosis Pediatrics versus adults Esophageal compliance/EndoFLIP
12:00 PM – 12:10 PM Video PDF Contextualizing Histologic Severity Margaret H. Collins, MD, University of Cincinnati, Cincinnati Children’s Hospital Medical Center Eosinophil count and EoEHSS Implications for widespread clinical use
12:10 PM – 12:20 PM Video PDF Correlates of Histological Severity and Outcomes Seema S. Aceves, MD, PhD, University of California San Diego, Rady Children’s Hospital Dave A. Katzka, MD, Mayo Clinic Thresholds for histologic severity Role of fibrosis
12:50 PM – 1:00 PM Defining EoE Clinical Severity Evan Dellon, MD, University of North Carolina School of Medicine
01:00 PM – 01:10 PM Making It Clinically Applicable Glenn Furuta MD, University of Colorado School of Medicine
01:10 PM – 02:40 PM Panel Discussion on Disease Severity, Future Research Directions Moderator: Seema S. Aceves, MD, PhD, University of California San Diego, Rady Children’s Hospital
